Effects of rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats.
- Author:
Ming HAO
;
Jia-qing TONG
;
Jun ZHANG
;
Mei-na WU
;
Jin-shun QI
- Publication Type:Journal Article
- MeSH: Amyloid beta-Peptides; adverse effects; Animals; Hippocampus; drug effects; Long-Term Potentiation; Maze Learning; Memory, Short-Term; drug effects; Neuronal Plasticity; drug effects; Peptide Fragments; adverse effects; Rats; Sirolimus; pharmacology
- From: Chinese Journal of Applied Physiology 2016;32(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe present study investigated the effects of rapamycin on Aβ1-42-induced deficits in working memory and synaptic plasticity.
METHODSAfter bilateral hippocampal injection of Aβ1-42 and rapamycinin rats, spontaneous alternation in Y-maze and in vivo hippocampal long-term potentiation (LTP) of rats were recorded. All data were analized by two-way repeated measures analysis of variance (ANOVA).
RESULTS(Hippocampal injection of Aβ1-42 alone impaired working memory of rats; (2) Rapamycin did not affect working memory of rats, but alleviated Aβ1-42-induced working memory deficits, compared with Aβ1-42 alone group; (Aβ1-42 remarkably suppressed in vivo hippocampal LTP of fEPSPs in the CA1 region; (4) Pretreatment with rapamycin prevented Aβ1-42-induced suppression of LTP.
CONCLUSIONThese data indicates that rapamycin could protect against Aβ1-42-induced impairments in working memory and synaptic plasticity in rats.