Effect of nano-SiO2 exposure on spatial learning and memory and LTP of hippocampal dentate gyrus in rats.
- Author:
Huan-rui SUN
;
Na ZHANG
;
Xue-wei CHEN
;
Gai-hong AN
;
Chuan-xiang XU
;
Qiang MA
- Publication Type:Journal Article
- MeSH: Animals; Dentate Gyrus; drug effects; Long-Term Potentiation; drug effects; Male; Maze Learning; drug effects; Memory; drug effects; Nanoparticles; adverse effects; Rats; Silicon Dioxide; adverse effects; Spatial Learning; drug effects
- From: Chinese Journal of Applied Physiology 2016;32(1):78-81
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of nano-SiO2 on spatial learning and memory.
METHODSTwenty-four male rats were randomly divided into 3 groups: control group (C group), low dose group (L group) and high dose group (H group). The rats were intragastrically administrated with nanometer particles at 25 and 100 mg/kg body weight every day for 4 weeks. After exposure, the ability of learning and memory of rats was tested by Morris water maze, and electrophysiological brain stereotactic method was used to test long-tear potentiation (LTP) in dentate gyrus (DG) of the rats.
RESULTSThe increase rate of body weight in H group was reduced significantly compared with C group ( P < 0.05). In the space exploration experiment of Morris water maze test, the escape latency of H group was longer than that of C group (P < 0.05). The rats of H group spent less time in finding the target quadrant (P < 0.05) . The rate of LP induction of H group was significantly lower than that of C group (P < 0.05). After high fre quency stimulation (HFS), The changes of amplitude of population spike (PS) of L group and H group were lower than those of C group significantly (P < 0.05, P < 0.01).
CONCLUSIONNano-SiO₂may result in impairment of spatial learning and memory ability by reducing the rate of LTP induction and the increase of PS in hippocampus.