Effect of acupuncture on the expression of Bcl-xl and BDNF of retina in rabbits with chronic intraocular hypertension.
- Author:
He SUN
1
;
Hui ZHANG
;
Bai-song LIN
Author Information
- Publication Type:Journal Article
- MeSH: Acupuncture Therapy; Animals; Brain-Derived Neurotrophic Factor; genetics; metabolism; Chronic Disease; therapy; Disease Models, Animal; Female; Gene Expression; Humans; Male; Ocular Hypertension; genetics; metabolism; therapy; Rabbits; Random Allocation; Retina; metabolism; bcl-X Protein; genetics; metabolism
- From: Chinese Acupuncture & Moxibustion 2010;30(8):661-664
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the protection effects of acupuncture on glaucomatous optic nerve damage and its mechanism.
METHODSExperimental glaucoma model was induced by intracameral injection of compound Carbomer solution in rabbits. After 28 days, ocular tension returned to normal by filtration surgery. Twenty rabbits (40 eyes) were randomly divided into a model group, an acupuncture group, a neurotrophy group and a nomal control group, 5 cases in each group. The acupuncture group was treated with acupuncture at bilateral "Qiuhou" (EX-HN 7),"Fengchi" (GB 20) and "Xingjian" (LR 2), twice a day. The neurotrophy group was treated with intramuscular injection of Vitamin B1 (100 mg) and Vitamin B12 (500 microg), once a day, and the other groups with no treatment. The expressions of Bcl-xl and BDNF in rabbits retina were observed after 4 weeks.
RESULTSAt the end of the experiment, the positive expression cells of Bcl-xl and BDNF were (31.20 +/- 5.97) per mm2 and (6.3 +/- 1.89) per mm2 in the acupuncture group, being significantly higer than (26.70 +/- 4.32) per mm2 and (4.0 +/- 1.89) per mm2 in the model group (both P<0.05).
CONCLUSIONAcupuncture can raise the expression of Bcl-xl and BDNF of retina, so as to prevent optic nerve damage caused by intraocular hypertension.
