A case of eosinophilic pneumonia under chemotherapy with the combination of 5-fluorouracil and leucovorin for colon cancer.
- Author:
Chang Kil JUNG
1
;
Shin Ae LEE
;
Jong Seung PARK
;
Sung Hyun KIM
;
Hyuk Chan KWON
;
Jae Seok KIM
;
Hyo Jin KIM
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. kimhj@mail.donga.ac.kr
- Publication Type:Case Report
- Keywords:
5-Fluorouracil;
Leucovorin;
Eosinophilic Pneumonia
- MeSH:
Bronchoalveolar Lavage;
Bronchoscopy;
Colon*;
Colonic Neoplasms*;
Diarrhea;
Drug Therapy*;
Dyspnea;
Eosinophils*;
Female;
Fluorouracil*;
Humans;
Leucovorin*;
Middle Aged;
Mucositis;
Pulmonary Eosinophilia*
- From:Korean Journal of Medicine
2003;65(Suppl 3):S863-S866
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The combination of 5-fluorouracil and leucovorin is the most commonly used chemotherapeutic agents in colon cancer. The most frequent adverse effects include mucositis, diarrhea and myelosuppression. But it has never been reported that eosinophilic pneumonia developed. A 50-year-old woman with a history of colon cancer was treated by chemotherapy with a combination of 5-fluorouracil and leucovorin. Progressive dyspnea and bilateral pulmonary interstitial infiltrates developed. Bronchoscopy with bronchoalveolar lavage confirmed pulmonary eosinophilia. Clinical and radiologic aspects of eosinophilic pneumonia cleared after discontinuation of chemotherapy. We report the first case of eosinophilic pneumonia induced by 5-fluorouacil and leucovorin administration in a patient with colon cancer.
