Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals.
- Author:
Xiao-Yu ZHANG
1
;
Wen-Guang LI
;
Tian-Zhen ZHENG
;
Wei LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta; drug effects; In Vitro Techniques; Muscle Contraction; drug effects; Muscle, Smooth, Vascular; drug effects; physiology; Norepinephrine; pharmacology; Platelet Aggregation; drug effects; Potassium Chloride; pharmacology; Proanthocyanidins; pharmacology; Rabbits; Rats; Rats, Wistar; Seeds; chemistry; Vitis; chemistry
- From: Chinese Journal of Applied Physiology 2005;21(4):383-386
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study effects of proanthocyanidins (PA) on contractile activity of isolated aortic smooth muscle in rats and rabbit platelet aggregation.
METHODSIsolated rat aortic muscle rings were adopted to observe the effects of PA on their contraction induced by noradrenaline (NA) or KCl, and their tensions were recorded by BL-310 experimental system of biological function. Rabbit platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP), and collagen (Coll) was assayed by turbidimetry.
RESULTSPA could significantly inhibit the contraction induced by NA (10(-6) mol/L), low the concentration-response curves of NA and the maximal response on the endothelium-intact or endothelium-denuded aortic rings. But PA couldn't relax the aortic rings precontracted with KCl and had no influence on rabbit platelet aggregation induced by AA, ADP, and Coll.
CONCLUSIONPA can inhibit the contraction induced by NA but not by KCl on isolated rat aortic rings. It also has no influence on rabbit platelet aggregation.
