Protecting effect of human-derived neurotrophin-6 on retrogradely degenerated motoneurons of facial nucleus of rats.
- Author:
Cheng-Wu ZHANG
1
;
Zi-Cheng LI
;
Li LI
;
Yu ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Facial Nerve; cytology; Humans; Motor Neurons; drug effects; pathology; Nerve Growth Factors; pharmacology; Neuroprotective Agents; pharmacology; Rats; Rats, Sprague-Dawley
- From:Chinese Journal of Applied Physiology 2005;21(4):397-400
- CountryChina
- Language:Chinese
-
Abstract:
AIMThe protecting effect of human-derived neurotrophin-6 (NT-6) on injured neurons was investigated to test the neurobiological characteristics of human-derived NT-6.
METHODSAdult SD rats were used and divided into two groups, normal control group and experiment group. The right facial nerve of the experimental rats was sectioned. The experimental animals were subdivided into three groups, blank control group, NT-6 group and saline control group. The rats were raised for two weeks. Brain stem of the rats was removed and transversely sliced. Nissle stain and ChAT immunohistochemical stain of the slices were carried out to observe the role of NT-6 in protecting facial motoneurons.
RESULTSThe number of the ChAT positive neurons and the intensity of Nissle stain in the facial nucleus of NT-6 group were significantly augmented compared with that of the blank and saline control groups.
CONCLUSIONThe human-derived NT-6 could partially protect the facial motoneurons from retrograde degeneration induced by their axon damage.
