Effects of Chinese herbs on glucocorticoid receptor in rat brain regions with chronic immobilization stress.
- Author:
Jia-Xu CHEN
1
;
Jian-Xin YANG
;
Xin ZHAO
;
Zhu-Feng WANG
;
Guang-Xin YUE
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; metabolism; Drugs, Chinese Herbal; pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; drug effects; metabolism; Restraint, Physical; Stress, Physiological
- From:Chinese Journal of Applied Physiology 2005;21(4):402-406
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the changes of glucocorticoid receptor (GR) in rat brain regions with chronic immobilization stress and the influence of Chinese herbs.
METHODSWe copied the rat model of chronic immobilization stress (180 min daily, repeated 7 days or 21 days), and characterized the changes of GR in hippocampus CA1, cortex, dentate gyrus via immunohistochemistry integrated image analysis.
RESULTSThe contents of glucocorticoid receptors in hippocampus CA1 , cortex, dentate gyrus were increased and the intensity of immunity reaction was significantly stronger in the model group of 7 days than that in the normal control group (P < 0.05). The contents of GR were significantly decreased and the intensity of immunity reaction was weaken in the model group of 21 days (P < 0.05).
CONCLUSIONCompared with the model group of 21 days, the contents of GR were significantly increased and immunity reaction was intensified in three groups of treatment with Chinese herbs (P < 0.05), in which the group treated with soothing-liver herbs Xiaoyaopowder was the best.
