Effects of shenmai injection on lipid peroxidation in the lung following with ischemia/ reperfusion (I/R) injury of limb.
- Author:
Yang-Lei WANG
1
;
You-Ling JING
;
Jing-Xia ZHAO
;
Guo-Xian DUAN
;
Xiu-Hong YANG
;
Bo HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Combinations; Drugs, Chinese Herbal; pharmacology; therapeutic use; Extremities; blood supply; Ischemia; metabolism; Lipid Peroxidation; drug effects; Lung; metabolism; Malondialdehyde; metabolism; Rabbits; Reperfusion Injury; drug therapy; metabolism; Superoxide Dismutase; metabolism
- From: Chinese Journal of Applied Physiology 2006;22(1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the effects of shenmai (Chinese transitional medicine) injection on lipid peroxidation in the lung following with ischemia/reperfusion (I/R) injury of limb.
METHODSThe models of I/R injury of limb were constructed in rabbits. Superoxide dismutase (SOD) and malondialdehyde (MDA) in into and out-flowing pulmonary blood (IPB, OPB) and lung tissue were measured, as well as the effects of shenmai injection were observed.
RESULTSCompared with sham group, the activity of SOD in IPB, OPB and lung tissue were decreased, and the content of MDA was increased after 4 h ischemia followed by 4 h reperfusion. SOD increased and MDA decreased significantly by icy shenmai injection 30 min before reperfusion. The correlation analysis indicated that MDA was negatively correlated with SOD .
CONCLUSIONOxygen free radicals metabolic confusion of lung occurred in the course of I/R, shenmai injection can alleviate lipid peroxidation, get rid of free radicals and inhibit the damage of lung.
