Therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion(SMAO) shock.
- Author:
You-Ling JING
1
;
Chun-Xiu ZHAO
;
Guo-Xian DUAN
;
Yan-Lei WANG
;
Yong-Qi HU
;
Lian-Yuan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Female; Lung; metabolism; Lung Injury; drug therapy; etiology; metabolism; Male; Mesenteric Artery, Superior; pathology; Mesenteric Vascular Occlusion; complications; drug therapy; metabolism; Rabbits; Shock; complications; drug therapy; metabolism; Zinc Sulfate; therapeutic use
- From: Chinese Journal of Applied Physiology 2006;22(1):90-93
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study preventive and therapeutic effect of zinc sulfate on lung injury during superior mesenteric artery occlusion (SMAO) shock and their mechanism of action.
METHODSModel of rabbit SMAO shock was made. The effect of zinc sulfate on the malondialdehyde (MDA) in erythrocyte membrane and plasma, oxidase (XOD) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD and pulmonary surfactant (PS) in lung tissues homogenate were observed.
RESULTSThe administration of zinc sulfate decreased MDA and XOD, prevented the reduction of SOD and PS, and alleviated lung injury.
CONCLUSIONIt is suggested that lung is injured during SMAO shock and zinc sulfate possesses preventive and therapeutic effect, through stabilized membrane.
