Effects of melatonin on the induction of long term potentiation in the hippocampal CA3 area of rats.
- Author:
Rong YANG
1
;
Hong-Mei XIAO
;
Dang HUANG
;
Xin-Wu HU
;
Xiao-Ling HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; CA3 Region, Hippocampal; drug effects; physiology; Electric Stimulation; Long-Term Potentiation; drug effects; Male; Melatonin; pharmacology; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2006;22(2):195-199
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of melatonin on the induction of LTP in CA3 area of hippocampus and to investigated its possible mechanisms.
METHODSMelatonin and other drugs (Tacrine or DNQX) were microinjected into the CA3 area. By using extracellular electrophysiological recordings to observe the changes of the slope of fEPSP in the CA3 area.
RESULTS(1) Evoked potential and the induction of LTP were depressed by different concentration of melatonin (0.2 microg/microl, 1 microg/microl and 5 microg/microl). As the melatonin concentration increased, the induction of LTP was blocked more obviously. (2) Melatonin could attenuate the excitation effect of Tacrine (inhibitor of AChE) on LTP. (3) Inhibition of the melatonin-induced on LTP attenuated by DNQX.
CONCLUSIONThe application of melatonin in rats inhibits the induction of LTP in the hippocampal CA3 area. The action of melatonin on the induction of LTP may be through the modulation of not only non-NMDA receptors but also cholinergic system.
