The effects of sodium salicylate on the expression of GABAalpha, NR1 and hearing response properties of inferior colliculus neurons in mice.
- Author:
Shi-Hua YIN
1
;
Shu-Sheng GONG
;
Kai-Sheng YAN
;
Sui LI
;
Pei CHEN
;
Guang Li CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acoustic Stimulation; Animals; Inferior Colliculi; drug effects; metabolism; physiology; Mice; Mice, Inbred Strains; Neurons; drug effects; metabolism; physiology; Receptors, N-Methyl-D-Aspartate; metabolism; Sodium Salicylate; pharmacology; gamma-Aminobutyric Acid; metabolism
- From: Chinese Journal of Applied Physiology 2006;22(2):200-205
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effects of sodium salicylate on the expression of GABAalpha NR1 and hearing response properties of inferior colliculus neurons in mice.
METHODSThirty-six kunming mice were divided into three groups (A, B, C,). The expression of GABAalpha NR1 were measured by using RT-PCR. The intensity-rates functions, intensity-latency functions and frequency-turning curves were recorded by extracellular electrophysiological recording techniques.
RESULTS(1) The expression of GABAalpha mRNA of B group was decreased remarkably than the control group (A group, P < 0.05), there weren't noticeable differences between A group and C group (P > 0.05). The expression of NR1 mRNA of B group was increased remarkably than the control group (A group, P < 0.01), there were noticeable differences between A group and C group P < 0.05). (2) The intensity-rates functions, intensity-latency functions were monotonic while the frequency-turning curves were more broad when sodium salicylate was given. (3) The intensity-rates functions, intensity-latency functions were non-monotonic while the frequency-turning curves were sharpened after lidocaine was given.
CONCLUSIONS(1) The results suggested that administration of sodium salicylate decreased the expression of GABAalpha while increased the expression of NR1mRNA. (2) The intensity-rates functions, intensity-latency functions were monotonic, the frequency-turning curves were more broad when salicylate was given and the changes above could be reversed by given lidocaine.
