Analysis of polymorphisms of mitochondrial DNA in 3 ethnic groups of Guizhou.
- VernacularTitle:贵州三个少数民族群体线粒体DNA多态性研究
- Author:
Ling-yan REN
1
;
Yan HE
;
Ting ZHANG
;
Chan-juan WANG
;
Zhi-zhong GUAN
;
Keren SHAN
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; ethnology; genetics; China; ethnology; DNA, Mitochondrial; genetics; Humans; Male; Pedigree; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2013;30(5):626-631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the population genetics characteristics of mitochondrial DNA (mtDNA) in Gelao, Mulao, Maonan ethnic groups from Guizhou.
METHODSMinisequenceing and restriction fragment length polymorphism (RFLP) were used to analyze 12 single nucleotide polymorphism (SNPs) of mitochondrial DNA in the 3 ethnic groups.
RESULTSA total of 30 haplotypes were detected in 156 samples. The distribution of H1, H23 had differed between Mulao, Maonan and Gelao, respectively, and so did M7 among the three groups. The difference was statistically significant (P < 0.05). Mulao, Maonan had respectively differed from Gelao and the difference was also statistically significant (P < 0.05).
CONCLUSIONThere was a great similarity in the distribution of haplotypes of the mtDNA among the three ethnic groups, except for some difference in the distribution of certain haplotypes.
