Association of RNASET2 gene polymorphisms and haplotypes with Graves disease in Han Chinese population from coastal regions of Shandong.
- Author:
Bao-ping WANG
1
;
Lin HAN
;
Jing-jie TONG
;
Yan WANG
;
Zhao-tong JIA
;
Ming-xia SUN
;
Hai-li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; Child; Female; Gene Frequency; Genetic Predisposition to Disease; Graves Disease; genetics; Haplotypes; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Ribonucleases; genetics; Tumor Suppressor Proteins; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2013;30(6):693-696
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of RNASET2 gene polymorphisms and haplotypes with Graves disease (GD) in Han Chinese population from coastal regions of Shandong Province.
METHODSA total of 471 GD patients and 472 controls were enrolled. Genotypes of single nucleotide polymorphisms (SNPs) in RNASET2 gene were determined with a Taqman probe on a Fluidigm EPl platform. Haplotypes and their frequencies were analyzed with a SHEsis online software.
RESULTSThere was a significant difference in allele frequencies of rs3777722, rs3777723 and rs9355610 between the GD patients and the controls (P=0.018; P=0.028; P=0.021).Allele frequencies of rs3777722 and rs9355610 were significantly lower in GD than in the controls (P=0.018, P=0.021). Haplotypes A-A-C-A and A-A-T-A were significantly more common in the control group compared with the GD group (P=0.046, OR=0.448, 95%CI:0.200-1.006; P=0.049, OR=0.823, 95%CI:0.678-0.999). The frequency of C-G-C-G haplotype was significantly higher in GD patient group than the control group (P=0.018).
CONCLUSIONRNASET2 gene polymorphisms and haplotypes are associated with GD in Han population from coastal areas of Shandong Province. rs3777722 and rs9355610 may contribute to the risk for GD.
