Association between matrix metalloproteinase-10 gene polymorphisms and instability of carotid plaque.
- VernacularTitle:基质金属蛋白酶-10基因多态性与颈动脉斑块易损性的相关性
- Author:
Feng ZHU
1
;
Xiao-ping JIN
;
Mi-wu HUANG
;
Min ZHU
;
Qiao-ling CHEN
;
Feng WANG
;
Xiao-fei HU
;
Wan-fen WANG
;
Wei-ling LI
;
Cai LI
;
Zong-ya ZHU
;
Zhou ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Matrix Metalloproteinase 10; genetics; Middle Aged; Plaque, Atherosclerotic; enzymology; genetics; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2013;30(6):711-715
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between 2 single nucleotide polymorphisms (SNPs) located in exonic regions of matrix metalloproteinase-10 (MMP-10) gene and instability of carotid plaques in a Han Chinese population.
METHODSFive hundred and eighty-five patients were divided into carotid vulnerable plaque group (n=206) and stable plaque group (n=379) based on results of carotid B-mode ultrasonography. The SNPs were genotyped by real-time polymerase chain reaction using an ABI 7300 TaqMan platform.
RESULTSThe distribution of rs17435959 between the two groups was significantly different at both genotypic (GC+CC vs. GG, P=0.006, OR=2.012) and allelic levels (C vs. G, P=0.001,OR=2.160). Above differences have remained significant with binary logistic regression analysis (P=0.007, OR=2.022; P=0.002, OR=2.104). The minor allele frequency of rs17293607 was 0.56%.
CONCLUSIONAbove findings suggested that rs17435959 of the MMP-10 gene is associated with carotid vulnerable plaque in ethnic Chinese Hans. The C allele may be a susceptible predictor for carotid vulnerable plaque.
