Association study of PRDM16 gene polymorphisms with essential hypertension in Xinjiang Uygur population.
- Author:
Nan-fang LI
1
;
Hong-mei WANG
;
Yun-wei BI
;
Ling ZHOU
;
Xiao-guang YAO
;
Zhi-tao YAN
;
Fei-ya ZU
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Blood Pressure; genetics; DNA-Binding Proteins; genetics; Essential Hypertension; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; genetics; Male; Middle Aged; Polymorphism, Genetic; Transcription Factors; genetics
- From: Chinese Journal of Medical Genetics 2013;30(6):716-720
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of polymorphisms of PR domain containing 16 gene (PRDM16) with essential hypertension in ethnic Uygur population from Xinjiang, China.
METHODSFunctional regions of the PRDM16 gene were sequenced in 48 Uygur subjects with essential hypertension selected from 480 hypertensive patients and 819 normotensive controls. Representative variations were genotyped with TaqMan-PCR method. Association of variations of PRDM16 gene with hypertension was analyzed.
RESULTSFor the 4 genotyped representative variations (rs2236518, rs2282198, rs2493292 and rs870171), no significant difference in genotype distribution and allele frequencies has been found between the patient and control groups (P>0.05). By ANOVA analysis, none of the polymorphisms was significantly associated with systolic or diastolic blood pressure (P>0.05). Nor was significant difference in haplotypic frequencies between the two groups detected (P>0.05).
CONCLUSIONWe have found no association between the four polymorphisms (rs2236518, rs2282198, rs2493292 and rs870171) of the PRDM16 gene with essential hypertension in ethnic Uygur population from Xinjiang.
