Association of 15 short tandem repeats loci with aggressive behavior.
- Author:
Chun YANG
1
;
Huajie BA
;
Haiying YU
;
Zhiqin GAO
;
Hanqing ZHAO
;
Jian SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aggression; Alleles; Genetic Predisposition to Disease; Genotype; Humans; Male; Mental Disorders; genetics; Microsatellite Repeats
- From: Chinese Journal of Medical Genetics 2014;31(1):101-105
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between aggressive behaviors and 15 short tandem repeats (STRs) loci.
METHODSPeripheral blood samples from 541 army men with aggressive behaviors and 459 healthy individuals were collected. All sample were amplified with a AmpFlSTR Identifiler(TM) system and separated by electrophoresis to compare the genotypic and allelic frequencies of 15 STRs (CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, THO1, TPOX and vWA) in the two groups.
RESULTSA significant difference was found in allelic and genotypic frequencies at loci D2S1338 and D19S433 (P< 0.01) between the two groups, but not for the remaining 13 STR loci (P> 0.05). Univarite analysis also showed a significant difference for allele 16, genotypes 19-22, 22-24 on D2S1338 and genotypes 13-14.2 on D19S433 between the two groups (P= 0.0018, P= 0.0001, P= 0.0003, P= 0.0000), with the OR values being 7.380 (95%CI: 1.701-32.028), 0.051(95%CI: 0.007-0.388), 13.933(95%CI: 1.845-105.717), 0.349 (95%CI: 0.216-0.564), respectively.
CONCLUSIOND2S1338 and D19S433 may be associated with aggressive behavior. Allele 16 and genotype 22-24 on D2S1338 may be susceptible factors for the disease, whilst genotypes 19-22 on D2S1338 and 13-14.2 on D19S433 may confer a protective effect on it.
