Association of three polymorphisms in the 3' untranslated region of the HLA-G gene with systemic lupus erythematosus in a population from Yunnan.
- Author:
Tingting CHEN
1
;
Jun LIN
;
Song JIN
;
Sha MA
;
Liang YU
;
Kai HUANG
;
Xiaoqin HUANG
;
Jiayou CHU
;
Zhaoqing YANG
Author Information
- Publication Type:Journal Article
- MeSH: 3' Untranslated Regions; genetics; Case-Control Studies; China; Female; Genetic Predisposition to Disease; HLA-G Antigens; genetics; Humans; Lupus Erythematosus, Systemic; genetics; Male; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2014;31(2):228-232
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of three polymorphisms (14-bpINS/DEL, +3035C/T and +3142C/G) in the 3' untranslated region (3'UTR) of HLA-G gene and systemic lupus erythematosus (SLE) in Yunnan.
METHODSA case-control study has been carried out on 206 SLE patients and 212 healthy controls. Genotypes of 14-bpINS/DEL (rs1704), +3035C/T (rs17179108) and +3142C/G (rs1063320) loci of 3'UTR of the HLA-G gene were determined with DNA sequencing.
RESULTSAllelic and genotypic frequencies of 14-bpINS/DEL and +3142C/G did not differ significantly between the two groups (P > 0.05). The frequencies of +3035T allele was significantly higher in the SLE group compared with the control group (P < 0.01, OR=1.604, 95% CI: 1.186-2.169). With a dominant inheritance model, the odd ratio of dominant genotype (CT+TT) was 2.004 (95% CI: 1.345-2.987, P=0.0006) in the SLE group.
CONCLUSIONThe 14-bpINS/DEL and +3142C/G polymorphisms in the 3'UTR of the HLA-G gene are not associated with susceptibility to SLE in Yunnan, whilst the T allele of +3035C/T may be a risk factor for SLE.
