Relationship between Line 1 methylation and clinical data of non-small cell lung cancer.

Xinneng Liu; Yongtang Jin; Peiwei XU; Chunmei Chen; Cong Tan

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Relationship between Line 1 methylation and clinical data of non-small cell lung cancer.

Author: Xinneng LIU ¹ ; Yongtang JIN ; Peiwei XU ; Chunmei CHEN ; Cong TAN
Author Information

1. Environmental Epigenetics Laboratory, Department of Environmental Medicine, Faculty of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China. Emailjinedu@zju.edu.cn.
Publication Type:Journal Article
MeSH: Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; genetics; metabolism; pathology; DNA Methylation; Female; Humans; Long Interspersed Nucleotide Elements; Lung Neoplasms; genetics; metabolism; pathology; Male; Middle Aged
From: Chinese Journal of Medical Genetics 2014;31(3):307-311
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the impact of Line-1 methylation on clinical features of non-small cell lung cancer and its connection with smoking and other living habits.
METHODSPyrosequencing was used to determine the extent of Line-1 methylation in cancer and adjacent tissues derived from 197 patients with primary non-small cell lung cancer. Non-conditional logistic regression analysis was performed to correlate the level of Line-1 methylation with clinical features and living habits of the patients.
RESULTSLine-1 methylation for cancer tissue and adjacent tissue has measured 68.20±11.63 and 78.90±2.09, respectively (P < 0.01), and has been associated with TNM staging, smoking history and histopathological types.
CONCLUSIONLung cancer tissue Line-1 methylation level is closely related with clinical features and smoking. There is also a correlation between histopathological types of lung cancer and relative hypomethylation of Line-1.