Possible mechanisms of Roux-en-Y gastric bypass treatment for type 2 diabetes mellitus.
- Author:
Guanglong DONG
1
;
Xiao XU
Author Information
1. Department of General Surgery, Chinese PLA General Hospital, Beijing 100853, China. gldong301@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Caloric Restriction;
Diabetes Mellitus, Type 2;
surgery;
Gastric Bypass;
Gastrointestinal Hormones;
Humans;
Insulin Resistance;
Insulin-Secreting Cells
- From:
Chinese Journal of Gastrointestinal Surgery
2014;17(7):737-740
- CountryChina
- Language:Chinese
-
Abstract:
Roux-en-Y gastric bypass(RYGB) is a classic procedure for the treatment of type 2 diabetes mellitus (T2DM), but it remains unclear why this procedure works. There might be several mechanisms that RYGB works through to treat T2DM, including calorie restriction and malabsorption, improvement of insulin resistance and β-cell functions, and altered secretion of gastrointestinal hormones. Altered levels of adipokines and serum bile acids might also play a role after RYGB. Future researches should concentrate on the exact mechanism of the altered hormone levels after RYGB, and whether different methods of gastrointestinal tract reconstruction could lead to various hormone levels.
