Analysis of early lymph node metastasis pattern and prognosis in thoracic esophageal squamous cell carcinoma.

Zhao MA; Peng Tang; Hongdian Zhang; Chuangui Chen; Zhentao YU

Return

Analysis of early lymph node metastasis pattern and prognosis in thoracic esophageal squamous cell carcinoma.

Author: Zhao MA ¹ ; Peng TANG ; Hongdian ZHANG ; Chuangui CHEN ; Zhentao YU
Author Information

1. Department of Esophageal Tumor, Cancer Institute and Hospital of Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Prevention and Therapy for Tumor of Tianjin City, Tianjin 300060, China. yuzhtao@hotmail.com.
Publication Type:Journal Article
MeSH: Carcinoma, Squamous Cell; pathology; surgery; Esophageal Neoplasms; pathology; surgery; Esophagectomy; Humans; Lymph Node Excision; Lymph Nodes; pathology; Lymphatic Metastasis; diagnosis; pathology; Prognosis; Retrospective Studies; Risk Factors; Survival Rate
From: Chinese Journal of Gastrointestinal Surgery 2014;17(9):884-887
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the pattern of early lymph node metastasis of thoracic esophageal squamous cell carcinoma and its prognostic value.
METHODSClinical and follow-up data of 126 patients with pathological stage pN1 of esophageal squamous cell carcinoma undergoing radical esophagectomy in our department from January 2005 to December 2008 were analyzed retrospectively. Impact of lymph node metastasis pattern on prognosis was investigated.
RESULTSThe relatively common sites of lymph node metastasis were upper mediastinum(53.8%), middle and lower thoracic paraesophageal(38.3%), right and left cardiac(34.4%) and the left gastric artery(36.8%). Univariate analysis showed that the lymph node metastasis of subcarinal, middle and lower thoracic paraesophageal and the left gastric artery was associated with 5-year survival rate. Multivariate analysis revealed that the presence of subcarinal and middle and lower thoracic paraesophagea lymph node metastasis was an independent risk factor of survival.
CONCLUSIONSUpper mediastinal, middle and lower thoracic paraesophageal, right and left cardiac and the left gastric artery are the earliest lymph node metastasis sites of esophageal squamous cell carcinoma. The presence of subcarinal and middle and lower thoracic paraesophagea lymph node metastasis is an independent risk factor of survival. Patient prognosis should be analyzed with lymph node metastasis pattern based on the 7th edition UICC-AJCC TNM classification system.