Timing of radiotherapy for locally advanced rectal cancer.
- Author:
Ji ZHU
1
;
Zhen ZHANG
Author Information
1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China. leo.zhu@126.com.
- Publication Type:Journal Article
- MeSH:
Chemoradiotherapy;
Humans;
Preoperative Care;
Prognosis;
Rectal Neoplasms;
pathology;
therapy
- From:
Chinese Journal of Gastrointestinal Surgery
2014;17(11):1072-1075
- CountryChina
- Language:Chinese
-
Abstract:
For locally advanced rectal cancer, multiple disciplinary team (MDT) has been the standard care. As a part of MDT, radiotherapy (RT) plays an important role in clinical practice. With mounting clinical evidence, RT is swifted from postoperative administration to preoperative. Compared to post-operative RT, pre-operative RT increased local control rate significantly, but not in DFS and OS. Two different preoperative RT models, short-course RT and long-course chemoradiotherapy demonstrated similar local control and long-term survival. However, a better tumor regression was observed in long-course CRT. In recent year, some small sample size studies, optimized the current pre-operative RT model, such as prolonging the interval between RT and surgery and adding consolidation chemotherapy (CT) in the interval, or adding induction CT before pre-operative RT. These optimizations decreased toxicities and increased treatment compliance, then improved the prognosis to a certain extent.
