Relationship between genetic polymorphism of NAT2 and susceptibility to urinary bladder cancer.
- Author:
Gang-yue HAO
1
;
Wei-dong ZHANG
;
Yong-he CHEN
;
Dao-xin ZHANG
;
Yu-hai ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Arylamine N-Acetyltransferase; genetics; Carcinoma, Transitional Cell; enzymology; genetics; pathology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Smoking; Urinary Bladder Neoplasms; enzymology; genetics; pathology
- From: Chinese Journal of Oncology 2004;26(5):283-286
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between genetic polymorphism of NAT2 and susceptibility to bladder cancer.
METHODSNAT2 genotypes were determined by PCR-RFLP method in 69 patients with bladder transitional cell carcinoma and 88 healthy controls.
RESULTSThe frequency of NAT2 slow genotypes was 26.1% (18/69) in patients compared with 14.8% (13/88) in controls (P < 0.05). Bladder cancer risk in patients with NAT2 slow genotypes was 2 fold as high as that in patients with NAT2 rapid genotypes. When NAT2 rapid genotypes/non-smoker were used as reference, bladder cancer risk increased to 5.8-fold (P < 0.05). Among the smokers with PY higher than 10, the patients showed a higher frequency of NAT2 slow genotype than controls (P < 0.05). It was also shown that the patients with slow NAT2 genotypes were more likely to have high grade tumor (P < 0.05) and advanced stage tumor (P < 0.01).
CONCLUSIONThe results suggest that NAT2 genetic polymorphism is associated with bladder cancer susceptibility. People with NAT2 slow genotype have higher bladder cancer risk.
