Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of breast cancer.
- Author:
Jun QI
1
;
Xiao-ping MIAO
;
Wen TAN
;
Chun-yuan YU
;
Gang LIANG
;
Wen-fu LÜ
;
Dong-xin LIN
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; Breast Neoplasms; genetics; China; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); genetics; Point Mutation; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Oncology 2004;26(5):287-289
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and risk of breast cancer among women.
METHODSTwo hundred seventeen cases with breast cancer and 218 matched controls were genotyped for the MTHFR C677T and A1298C polymorphisms by PCR-RFLP methods. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression model.
RESULTSWe found that the frequency of the MTHFR C677TT genotype among cases was significantly different from that among controls (32.7% vs. 24.8%; P = 0.02). The MTHFR C677TT genotype had an increased risk of breast cancer compared with the 677CC genotype (95% CI, 1.09 - 3.14). No significant association between the MTHFR C677T or A1298C polymorphism and risk of the cancer was observed.
CONCLUSIONThese findings suggest that 677CT polymorphism in MTHFR may be a genetic susceptibility factor for breast cancer among Chinese women.
