Transcatheter hepatic arterial chemoembolization and thymosin alpha1 in postoperative treatment of hepatocellular carcinoma.
- Author:
Shu-qun CHENG
1
;
Meng-chao WU
;
Han CHEN
;
Feng SHEN
;
Jia-he YANG
;
Wen-ming CONG
;
Yu-xiang ZHAO
;
Pei-jun WANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adjuvants, Immunologic; administration & dosage; Adult; Aged; Antibiotics, Antineoplastic; administration & dosage; Antineoplastic Agents; administration & dosage; Carboplatin; administration & dosage; Carcinoma, Hepatocellular; surgery; therapy; Chemoembolization, Therapeutic; Doxorubicin; administration & dosage; Female; Hepatectomy; Humans; Iodized Oil; administration & dosage; Liver Neoplasms; surgery; therapy; Male; Middle Aged; Mitomycin; administration & dosage; Neoplasm Recurrence, Local; prevention & control; Postoperative Period; Survival Rate; Thymosin; administration & dosage; analogs & derivatives
- From: Chinese Journal of Oncology 2004;26(5):305-307
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of postoperative transcatheter hepatic arterial chemoembolization (TACE) and thymosin alpha(1) (T(alpha1)) treatment on recurrence of hepatocellular carcinoma (HCC).
METHODSFrom Jan 2000 to Dec 2002, 57 patients with HCC were randomly divided into three groups: group A (n = 18) received hepatectomy plus postoperative TACE and T(alpha1), group B (n = 23) received hepatectomy plus postoperative TACE and group C (n = 16) received hepatectomy only. The recurrence rate, the time to tumor recurrence and the median survival for the three groups were investigated.
RESULTSFor group A, B and C, the 1 year recurrence rate was 83.3%, 87.0% and 87.5% (P = 0.926), respectively. The time to tumor recurrence was 7.0, 5.0 and 4.0 months (P = 0.039), respectively. The median survival was 10.0, 7.0 and 8.0 months (P = 0.002), respectively.
CONCLUSIONPostoperative TACE plus Talpha(1) treatment for HCC patients does not decrease the recurrence rate but may delay its occurrence and prolong surviving time.
