Expression of a plant associated human cancer antigen in breast cancer.
- Author:
Jun FU
1
;
Hai-mei TIAN
;
Ping QU
;
Mo LI
;
Xin-wen ZHENG
;
Zhen-hai ZHENG
;
Wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma, Mucinous; immunology; pathology; Adult; Aged; Antigens, Neoplasm; metabolism; Biomarkers, Tumor; metabolism; Breast; immunology; Breast Neoplasms; immunology; pathology; Carcinoma, Ductal, Breast; immunology; pathology; Carcinoma, Intraductal, Noninfiltrating; immunology; pathology; Female; Fibroadenoma; immunology; pathology; Humans; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; metabolism; Plants; immunology; Receptor, ErbB-2; metabolism
- From: Chinese Journal of Oncology 2004;26(7):403-405
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of a glycoprotein of plant origin in normal, benign and malignant breast tissues.
METHODSExpression of a plant glycoprotein was examined in 5 samples of normal breast tissues, 20 fibro-adenoma and 136 breast cancer by SABC immunohistochemical staining and the results were analyzed by SPSS statistics software.
RESULTSNo positive staining was detected in normal breast tissues (0/5). Weak staining was observed in 4 of 20 (20.0%) breast fibro-adenoma. Positive staining was demonstrated in 116 out of 136 (85.3%) breast cancer specimens. The differences were statistically significant. The expression of plant-associated human cancer antigen was related to pathological grade (P < 0.05), tissue invasiveness (P < 0.01) and recurrence (P < 0.05), but not to patients' age, tumor size and c-erbB-2 expression.
CONCLUSIONThe plant glycoprotein studied may be a human cancer-associated antigen which might be a potential marker of breast cancer.
