Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.
- Author:
Su-sheng SHI
1
;
Zu-gen HE
;
Kang SHAO
;
Fang ZHOU
;
Mei-hua XIONG
;
Wei HUANG
;
Ba-dong MU
;
Cui-yan ZHANG
;
Sen ZHANG
;
Yun-tian SUN
;
Jie HE
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; secondary; Adult; Aged; Carcinoma, Squamous Cell; metabolism; secondary; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; biosynthesis; genetics; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; metabolism; pathology; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Prognosis; RNA, Messenger; biosynthesis; genetics
- From: Chinese Journal of Oncology 2004;26(9):547-550
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between the overexpression of PKA RIalpha mRNA and cliniopathological parameters in lung cancer.
METHODSRT-PCR was used to detect the expression of PKA RIalpha mRNA in 54 cases with human lung cancer and matched normal tissues.
RESULTS(1) The expression of PKA RIalpha mRNA was significantly higher in cancer tissue (66.7%) than in normal tissues (20.4%) (P < 0.01). (2) The expression was significantly correlated with TNM stage (P < 0.01), being increased with TNM stage. (3) The expression was significantly higher in patients with positive lymph nodes than in those with negative lymph nodes (P < 0.01). (4) There were no significant associations of PKA RIalpha mRNA expression with histological type, differentiation grade or size of the tumor.
CONCLUSIONThis study indicates that the overexpression of PKA RIalpha mRNA may play an important role in the progression, metastasis and prognosis of lung cancer.
