Diagnosis, treatment and prognostic factors of adenoid cystic carcinoma of the palate.
- Author:
Wen-Sheng LIU
1
;
Ping-Zhang TANG
;
Yong-Fa QI
;
Li GAO
;
Zheng-Jiang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Carcinoma, Adenoid Cystic; diagnosis; secondary; therapy; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Lung Neoplasms; drug therapy; secondary; Male; Middle Aged; Neoplasm Recurrence, Local; Palatal Neoplasms; diagnosis; pathology; therapy; Palate; radiation effects; surgery; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate
- From: Chinese Journal of Oncology 2004;26(8):485-489
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical characteristics, diagnosis, treatment and prognosis of adenoid cystic carcinoma of the palate.
METHODSA retrospective review was conducted in 42 patients with adenoid cystic carcinoma of the palate treated in our hospital from 1967 to 1998. Statistical analysis was performed using the Kaplan-Meier method. Prognostic factors were analyzed by Log Rank test.
RESULTSThe overall 5-, 10-, 15-year accumulative survival rates were 85.0%, 61.8% and 28.1%, and the 5-, 10-, 15-year accumulative disease-free survival rates were 52.4%, 32.7% and 22.4%, respectively. The 5-, 10-, 15-year accumulative local recurrence rates were 25.2%, 50.9% and 73.1%, and the 5-, 10-, 15-year accumulative distant metastasis rates were 28.5%, 50.4% and 66.0% respectively. T stage, bone invasion, extent of tumor, local recurrence and distant metastasis were significant prognostic factors. Treatment method, dose and area covered by radiotherapy were related to the prognosis.
CONCLUSIONSurgery alone can be done for early lesions, and combination of surgery with radiotherapy should be adopted for advanced lesions in adenoid cystic carcinoma of the palate. Radiotherapic salvage could prolong the survival of the locally recurrent patients.
