Frequent genetic deletion of detoxifying enzyme GSTM1 and GSTT1 genes in nasopharyngeal carcinoma patients in Guangxi Province, China.
- Author:
Zhuo-lin DENG
1
;
Yi-ping WEI
;
Yun MA
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; China; Gene Deletion; Genetic Predisposition to Disease; Glutathione Transferase; genetics; Humans; Nasopharyngeal Neoplasms; enzymology; genetics
- From: Chinese Journal of Oncology 2004;26(10):598-600
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the genetic susceptibility to chemical carcinogens of nasopharyngeal carcinoma (NPC) patients in a high-risk area in Guangxi.
METHODSPCR technique was used to examine the frequency of glutathione S-transferase M1 and T1 gene deletion in a matched case-control study of 91 patients with NPC and 135 control subjects.
RESULTSThe deletion frequency of control subjects was 47.4% (65/135) for GSTM1 and 40.7% (55/135) for GSTT1, whereas that of NPC patients was 61.5% (56/91) for GSTM1 and 59.3% (54/91) for GSTT1 with statistically significant difference between the patients and the controls (P < 0.05 and P < 0.01). Furthermore, the frequency of codeletion of both genes was also higher in NPC patients than the control with statistically significant difference (chi2 = 12.533, P = 0.002).
CONCLUSIONIn high-risk area, nasopharyngeal carcinoma patients and local residents have high frequency of GSTM1 and/or GSTT1 gene deletion. It suggests that a genetic susceptibility to putative chemical carcinogens may be responsible for NPC clustering in the high-risk area studied.
