Relationship between heparanase mRNA expression in human gastric cancer and its clinicopathological features.
- Author:
Jun-qiang CHEN
1
;
Wen-hua ZHAN
;
Yu-long HE
;
Jun-sheng PENG
;
Jian-ping WANG
;
Zheng-xuan CHEN
;
Yi-hua HUANG
;
Shi-rong CAI
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; enzymology; pathology; Adult; Aged; Aged, 80 and over; Female; Glucuronidase; biosynthesis; genetics; Humans; Liver Neoplasms; metabolism; secondary; Lymph Nodes; pathology; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; RNA, Messenger; biosynthesis; genetics; Stomach Neoplasms; enzymology; pathology
- From: Chinese Journal of Oncology 2004;26(10):609-611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between heparanase mRNA expression and clinicopathological parameters in human gastric cancer.
METHODSRT-PCR was used to detect the expression of heparanase mRNA in 43 human gastric carcinomas and 10 adjacent normal gastric tissues.
RESULTSHeparanase mRNA was expressed in 29 of the 43 cases of gastric cancer with a positive rate of 67.4%, which was significantly higher than that in adjacent normal gastric tissues (P = 0.013). The expression level was higher in late-stage tumors (stage III and IV) than in early-stage tumors (stage I and II) (P = 0.001), in tumors with invasion to serosa than those without serosal invasion (P = 0.009), in tumors with lymph node metastasis than those without lymph node metastasis (P = 0.018), and in large-sized tumors than in small-sized ones (P = 0.009). The expression was not correlated with patients' age, sex, tumor location, histologic types, differentiation, peritoneal dissemination and liver metastasis (P > 0.05).
CONCLUSIONHeparanase might play an important role in the development of invasion and metastasis of gastric cancer.
