Influence of chemotherapy on Th1/Th2 cytokine switching in stomach cancer patients.
- Author:
Yan LI
1
;
Jing LIANG
;
Wen-bo LIU
;
Xiao-qun XU
;
Yue-ran ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; drug therapy; immunology; metabolism; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Female; Fluorouracil; administration & dosage; Humans; Interferon-gamma; metabolism; Interleukins; metabolism; Leucovorin; administration & dosage; Male; Middle Aged; Organoplatinum Compounds; administration & dosage; Stomach Neoplasms; drug therapy; immunology; metabolism; Th1 Cells; metabolism; Th2 Cells; metabolism
- From: Chinese Journal of Oncology 2004;26(12):732-734
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the influence of chemotherapy on the switching of Th1/Th2 cytokines in stomach cancer patients.
METHODSTh1/Th2 cytokine genes expressed by peripheral blood mononuclear cells of stomach cancer patients before and after chemotherapy were detected by RT-PCR.
RESULTSThe expression of Th2 cytokines was dominant in patients before chemotherapy, and the dominancy became less marked after chemotherapy.
CONCLUSIONThe immune deviation with Th2 predominance in stomach cancer patients has a tendency to become reversed after chemotherapy.
