Correlation study of expression levels of prostate-specific membrane antigen and prostate-specific antigen with Gleason score of prostate carcinoma.
- Author:
Jia-qiang REN
1
;
Zhong-qing CHEN
;
Li ZHENG
;
Qi CHEN
;
Hua LI
;
Hong-guang ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, Surface; metabolism; Biomarkers, Tumor; metabolism; Glutamate Carboxypeptidase II; metabolism; Humans; Male; Prostate-Specific Antigen; metabolism; Prostatic Neoplasms; metabolism; pathology
- From: Chinese Journal of Oncology 2004;26(12):735-738
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the correlation of prostate-specific membrane antigen (PSMA) and prostate-specific antigen (PSA) expression with Gleason score of prostate carcinoma.
METHODSMonoclonal antibodies against epitopes of PSMA extracellular domain were prepared, with which the expression of PSMA of prostate carcinoma (PC) was determined by immunohistochemical staining. Correlation of its expression with Gleason score of PC was statistically analyzed, and compared with that of PSA.
RESULTSEight hybridoma cell lines secreting monoclonal antibodies specific for PSMA were prepared. PSMA expression level was positively correlated with Gleason score. In poorly differentiated prostate carcinoma, the expression intensity of PSMA was higher than that of medium-and well-differentiated prostate carcinoma (P < 0.01). However, there was no correlation between level of PSA expression and Gleason score (P > 0.05).
CONCLUSIONPSMA expression level may be used as a useful surrogate marker in Gleason grading of prostate carcinoma. It may be a more suitable target than PSA in antibody mediated immunotherapy against poorly differentiated prostate carcinoma which is usually not sensitive to hormonal therapy.
