Oxaliplatin plus capecitabine as a second line chemotherapy for patients with advanced gastric cancer.
- Author:
Jun QIAN
1
;
Shu-kui QIN
;
Jing-feng MEI
;
Ying-xia CHEN
;
Zhi-jian SHAO
;
Ze-ming HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; adverse effects; therapeutic use; Capecitabine; Deoxycytidine; administration & dosage; analogs & derivatives; Drug Administration Schedule; Female; Fluorouracil; analogs & derivatives; Humans; Liver Neoplasms; drug therapy; secondary; Lymphatic Metastasis; Male; Middle Aged; Nausea; chemically induced; Neoplasm Staging; Neutropenia; chemically induced; Organoplatinum Compounds; administration & dosage; Remission Induction; Stomach Neoplasms; drug therapy; pathology
- From: Chinese Journal of Oncology 2004;26(12):746-748
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect and toxicity of oxaliplatin combined with capecitabine (Xeloda) as a second-line chemotherapy regimen for patients with advanced gastric cancer.
METHODSTwenty-four patients with advanced gastric cancer who had been treated by multiple chemotherapy regimens presenting poor responses were allotted. LX regimen (oxaliplatin 85 mg/m(2) in 2-hour infusion on D1 and D15, capecitabine 1250 mg/m(2)/d divided in two daily doses given from D1 to D14) was adopted. The cycles were repeated every 28 days. All patients received two or more cycles.
RESULTSAll 24 patients were evaluated after having received 2 to 6 cycles of chemotherapy, totally 92 cycles. The overall response rate was 29.2% (including 2 CR, 5 PR, 10 NC and 7 PD). The time to tumor progression (TTP) was 2 to 18 months (median 5 months), and duration of remission was 4 to 14 months (median 8 months). The major toxicities were bone marrow suppression and nausea/vomiting.
CONCLUSIONOxaliplatin combined with capitabine is effective as a secondary line regimen for patients with advanced gastric cancer. This protocol is active and well tolerated. Further clinical studies are warranted.
