Pathogenesis of human metapneumovirus infection and research on attenuated live vaccine.
- Author:
Mao-Zhi TANG
1
;
Ying DOU
;
Xiao-Dong ZHAO
Author Information
1. Department of Nephritic Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. tmzm0130@163.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Metapneumovirus;
immunology;
Paramyxoviridae Infections;
etiology;
prevention & control;
Vaccines, Attenuated;
immunology;
Vaccines, Synthetic;
immunology;
Viral Vaccines;
immunology
- From:
Chinese Journal of Contemporary Pediatrics
2014;16(5):548-554
- CountryChina
- Language:Chinese
-
Abstract:
Numerous studies have indicated that human metapneumovirus (hMPV) is an important viral pathogen in acute respiratory infections in children, presenting similar manifestations with respiratory syncytial virus (RSV). HMPV infection peaks in the winter-spring season and is more prevalent in younger ages, especially in children less than 1 year old. Host innate immune response has been implicated in recognition of pathogen-associated molecular patterns (PAMPs) of the virus. This recognition occurs through host pattern recognition receptors (PRRs). Toll like receptors (TLRs) are one of the largest class of PRRs which initiate and regulate adaptive immune responses. Some studies have indicated that TLR 3 and TLR 4 may play critical roles in hMPV infection. Construction of recombinant mutant viruses lacking one or two N-linked glycosylation sites in the F protein by using site-directed mutagenesis and reverse genetics may be helpful for developing attenuated live vaccines.
