Advances in pathogenesis and correlated clinical research of hypercoagulability in β thalassemia.
- Author:
Rong-Yu LV
1
;
Fei-Qiu WEN
;
Jie YU
Author Information
1. Shenzhen Children's Hospital of Chongqing Medical University, Shenzhen, Guangdong 518026, China. fwen62@126.com.
- Publication Type:Journal Article
- MeSH:
Erythrocyte Aggregation;
Humans;
Thrombophilia;
etiology;
prevention & control;
beta-Thalassemia;
complications
- From:
Chinese Journal of Contemporary Pediatrics
2014;16(7):774-778
- CountryChina
- Language:Chinese
-
Abstract:
This article summarizes the pathogenesis of hypercoagulability in β thalassemia patients, including platelet activation, alteration of red blood cell membranes, abnormal expression of adhesion molecules on vascular endothelial cells and iron overload. Clinical evidence, clinical manifestations of hypercoagulable state and thrombosis in β thalassemia and the effect of splenectomy on hypercoagulable state were reviewed. Strategies to prevent and treat the thromboembolic events in β-thalassemia intermedia are also discussed, including transfusion therapy to raise hemoglobin levels, avoidance or delay of splenectomy and a number of treatments in the exploration.
