Specific T.cell responses to Mycobacterium tuberculosis protein ESAT-6 in Chinese HIV positive individuals
10.3760/cma.j.issn.1003-9279.2008.02.015
- VernacularTitle:HIV感染者中结核杆菌ESAT-6蛋白特异性T细胞反应的检测
- Author:
Bin ZHANG
1
;
Wen-Hui LUN
;
Jun CHENG
;
Long-Feng ZHAO
;
Xing-Wang LI
;
Ning HAN
;
Qi WANG
;
Yun-Lei LIANG
;
Yu MAO
Author Information
1. 山西医科大学第一临床医学院
- Keywords:
HIV;
Infection;
Mycobo-cterium tuberculosis;
Immunoenzyme techniques
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(2):124-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect TB specific T cell responses by using the recombinant ESAT-6 protein as stimulus in Chinese HIV infected patients. Methods ELISPOT-IFN-γ assay by using the recombinant ESAT-6protein as stimulus to detect specific T cell responses in HIV( + ) patients with or without clinical manifestation of TB diseases. Results Recombinant ESAT-6 protein specific T cell responses show significant high frequencies in both of TB patients with or without HIV infection than that in the healthy control and HIV ( + ) group without clinical TB diseases. Conclusions The ELISPOT-IFN-γ assay by using recombinant ESAT-6 protein as stimulus could be used in diagnoses of TB infection in Chinese HIV infected patients.
