Characterization of rabies virus phosphoprotein in high prevalence provinces of China.
- Author:
Xiao-Guang WANG
1
;
Xiao-Yan TAO
;
Hao LI
;
Miao SONG
;
Jia-Liang DU
;
Qiang ZHANG
;
Zhao-Jun MO
;
Kai-Jiao ZHOU
;
Hong ZHANG
;
De-Fang DAI
;
Ding-Ming WANG
;
Jin-Zhu ZHOU
;
Qing TANG
;
Guo-Dong LIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; China; epidemiology; Dog Diseases; epidemiology; virology; Dogs; Humans; Molecular Sequence Data; Phosphoproteins; genetics; Phylogeny; Prevalence; Rabies; epidemiology; veterinary; virology; Rabies virus; classification; genetics; isolation & purification; Viral Structural Proteins; genetics
- From: Chinese Journal of Experimental and Clinical Virology 2008;22(3):165-167
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVECharacterization of rabies virus phosphoprotein through analyzation of genetic variations about rabies virus phosphoproteins in high-incidence regions in China.
METHODSThe nucleotide sequence of the P gene of Guangxi, Guizhou and Hunan provinces positive sample's were sequenced, and the P region's similarity and phylogenetic analyses were completed by using softer wares.
RESULTSThe similarity of P region's nucleotide sequence is 82.1%-100%, while, the similarity of amino acid sequence is 87.5%-100%. A little variation in phosphoprotein cannot influence its biological functions.
CONCLUSIONAll rabies viruses isolated from Guangxi, Guizhou and Hunan provinces belong to genotype 1 and share same phylogenesis and same genome characteristic; Virus distribution presents unique Characterization; Some virus isolates from Hunan province and Thailand may come from the same virus.
