Characterization of rabies virus phosphoprotein in high prevalence provinces of China

VernacularTitle:中国狂犬病高发地区狂犬病毒磷蛋白基因特点分析
Author: Xiao-Guang WANG ¹ ; Xiao-Yan TAO ; Hao LI ; Miao SONG ; Jia-Liang DU ; Qiang ZHANG ; Zhao-Jun MO ; Kai-Jiao ZHOU ; Hong ZHANG ; De-Fang DAI ; Ding-Ming WANG ; Jin-Zhu ZHOU ; Qing TANG ; Guo-Dong LIANG
Author Information

1. 中国疾病预防控制中心病毒病预防控制所
Keywords: Rabies virus; Phosphoproteins; Genes; Sequence analysis
From: Chinese Journal of Experimental and Clinical Virology 2008;22(3):165-167
CountryChina
Language:Chinese
Abstract: Objective Characterization of rabies virus phosphoprotein through analyzation of genetic variations about rabies virus phosphoproteins in high-incidence regions in China. Methods The nucleotide sequence of the P gene of Guangxi, Guizhou and Hunan provinces positive sample's were sequenced, and the P region's similarity and phylogenetic analyses were completed by using softer wares. Results The similarity of P region's nucleotide sequence is 82.1%-100%, while, the similarity of amino acid sequence is 87.5%-100%. A little variation in phosphoprotein cannot influence its biological functions. Conclusion All rabies viruses isolated from Guangxi, Guizhou and Hunan provinces belong to genotype 1 and share same phylogenies and same genome characteristic; Virus distribution presents unique Characterization; Some virus isolates from Hunan province and Thailand may come from the same virus.