Relation of viral genotypes to clinical features in children with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2008.03.012
- VernacularTitle:在慢性乙肝儿童中HBV基因型分布特性及与临床特征关系的研究
- Author:
Shi-Shu ZHU
1
;
Hong-Fei ZHANG
;
Hai-Bin WANG
;
Yi DONG
;
Da-Wei CHEN
;
Wen-Zhen JIA
;
Yu GAN
;
Ju-Mei CHEN
Author Information
1. 解放军第三〇二医院
- Keywords:
Hepatitis B virus;
Genotype;
Disease attributes;
Liver/pathology
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(3):192-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation of HBV genotypes to clincal features in children with chronic hepatitis B. Methods The genotypes of serum HBV DNA from 404 children with chronic hepatitis B were determined by PCR using type-specific primers. Results for the 404 children, genotype B in 99(24.5%), genotype C in 255 (70.5%). For the 75 children from south part of China, 29 were of genotype B (38.7%) and44 of genotype C (58.7%). For the 329 children from north part of China, 70 were of genotype B (21.3%) and241 of genotype C (73.3%). There were significant differences between the children from south part and those from north part of China in genotype B and C (P=0.002). Genotype B and C were not significantly correlated congener, age and mother-to-fetus transmission. There was no marked difference in liver injury severity (P=0.4796), serum HBeAg positivity, HBVDNA level, inflammatory degree of liver tissue (P=0.209)and liver fibrosis(P=0.177) between the children with genotype B and those with genotype C. Conclusion In children with HBV infection, genotype C accouts for 70.5% and genotype B for 24.5%. The genotypes are of regional difference in children with HBV infeciton. There are replication and liver pathological change between genotype Band genotype C.
