Study on T cell subsets in HIV/AIDS patients.
- Author:
Hai-Ying LI
1
;
Zhen-Huan CAO
;
Yun-Xia JI
;
Hao WU
;
Xin-Yue CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; immunology; virology; Adult; CD4 Lymphocyte Count; Case-Control Studies; Female; HIV; immunology; Humans; Male; Middle Aged; T-Lymphocyte Subsets; immunology
- From: Chinese Journal of Experimental and Clinical Virology 2008;22(4):284-286
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEAnalyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development.
METHODST cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM.
RESULTSWith diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different.
CONCLUSIONSThe peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.
