Study on T cell subsets in HIV/AIDS patients

VernacularTitle:HIV/AIDS患者外周血T淋巴细胞亚群的研究
Author: Hai-Ying LI ¹ ; Zhen-Huan CAO ; Yun-Xia JI ; Hao WU ; Xin-Yue CHEN
Author Information

1. 首都医科大学附属北京佑安医院
Keywords: HIV; Acquried immunodeficiency syndrome; Lymphocyte Subsets
From: Chinese Journal of Experimental and Clinical Virology 2008;22(4):284-286
CountryChina
Language:Chinese
Abstract: Objective Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development. Methods T cell subsets from 15 normal control subjects, 79 HIV/AIDS patients were detected by FCM. Results With diesase progression, CD4+ Naive cell counts and ratio wasboth decreased obviously(P<0.001); CD4+ Tcm cell counts was significantly decreased(P<0.001), CD4+ Tcm cell ratio was obviously higher (P=0.002) ; CD4+ TEM cell ratio was obviously increased(P<0.001); CD8+ T Naive cell counts and ratio was also decreased obviously(P<0.05);CD8+ TCM, TEM, TEMRA are not significantly different. Conclusions The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.