The measurement and significance of serum chemokine RANTES in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2008.04.018
- VernacularTitle:慢性乙型肝炎患者血清趋化因子RANTES水平的检测及意义
- Author:
Ka ZHANG
1
;
Qi-Huan XU
;
Lu-Biao CHEN
;
Xin SHU
;
Hong CAO
;
Gang LI
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B,chronic;
Chemokines,RANTES
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(4):293-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the serum chemokine RANTES level in patients with chronic hepatitis B among different clinical severity and to explore its passible reasons. Methods 144 patients with chronic hepatitis B were divided into mild-moderate(46), serious(51) or severe group(47) according to the different clinical severity and 18 normal cases were taken as normal control. The serum level of chemokine RANTES was detected with an ABC-ELISA assay. Statistical analysis was performed on the software of SPSS 13.0.Results The serum chemokine RANTES levels in patients with chronic hepatitis B (2227.06±790.80, 5878.49±3334.58, 3482.77±2315.62 ng/L in mild-moderate, serious and severe group respectively) were significantly higher than that in the normal control (329.46±152.00 ng/L). The differences between each two hepatitis groups were also statistically significant (P<0.05) and serum chemokine RANTES level in serious group was highest among them. Conclusion Serum chemokine RANTES level in patients with chronic hepatitis B elevates significantly and it might play an important role in the pathogenesis of chronic hepatitis B.
