Expression of intrahepatic CD4+ CD25+ regulatory T cells in patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2008.04.019
- VernacularTitle:慢性HBV感染患者肝组织内CD4+CD25+调节性T淋巴细胞的表达
- Author:
Yu-Ying YANG
1
;
Zhen-Wei LANG
;
Meng-Dong LAN
;
Xiao-Hong SHI
;
Pei-Qing MA
;
Bing SHEN
;
Pei-Zhi WANG
;
Dao-Zhen XU
Author Information
1. 北京地坛医院
- Keywords:
CD4 lymphocyte count;
CD25 lymphocyte count;
T-lymphocytes;
Hepatitis B,chronic;
Immune tolerance
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(4):296-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and distribution of intrahepatic CD4+ CD25+regulatory T cells in immuno-tolerant and immuno-elearanee phase of patients with chronic hepatitis B. Methods The expression of FoxP3 was detected in 19 cases of immuno-tolerant phase and 12 cases of immuno-clearance phase by immunohistochemistry. The relation between the intrahepatic expression of FoxP3 and the clinico-pathological features were analyzed. Results The positive signal of FoxP3 is located in nuclear of lymphocyte and mainly aggregated in portal areas as well as occasionally scattered in hepatic sinusoids. The expression of intrahepatic FoxP3 in the group of immuno-tolerant phase was significantly increased than those in normal control(P<0.01), and greatly decreased than those in immuno-clearance phase (P<0.01). No correlation was observed among the expression of intrahepatic FoxP3, ALT, levels of HBV DNA, HBeAg positive, in patients of immuno-clearanee phase, respectively. There were significant differences between immuuo-tolerant phase and immuno-clearance phase age, ALT, TBIL, PTA, HBV-DNA and detection of HBeAg but not in sex and family history of HBV infection. Conclusion CD4+ CD25+ regulatory T cells may play important roles in the clearance of HBV as well as in liver inflammation and injury during chronic HBV infection.
