Significance of human papillomavirus test in triage of patients with atypical squamous cell of undetermined significance
10.3760/cma.j.issn.1003-9279.2008.04.020
- VernacularTitle:人乳头状瘤病毒分型检测在宫颈细胞学诊断为ASCUS分层处理中的意义
- Author:
Jian ZHAO
1
;
Jin-Nian ZHOU
;
Ying-Jie YANG
;
Qin-Ping LIAO
Author Information
1. 北京大学第一医院
- Keywords:
Neoplasms,squamous cell;
Cervix diseases;
Colpascopy;
Papillomavims,human
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(4):299-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of human papillomavirus teat in triage of patients with atypical squamoas cell of undetermined significance (ASCUS) diagnosed by cervical cytology. Methods Human papillomavirus teat,colposcope and cervical biopsy were performed in 184 patients with a referral diagnosis of ASCUS by cervical cytology. Results Confirmed by pathological diagnosis of cervical biopsy, 112 cases were chronic inflammation(60.87%),33 CIN Ⅰ (17.93%),17 CIN Ⅱ (9.24%),8 CIN Ⅲ (4.35%),4 cervical squamous carcinoma (2.17%) and 10 condyloma (5.43%). Of the 184 women with cytological ASCUS, 124(67.39%) cases were positive in high-risk HPV test among which 66 cases were histologically confirmed as chronic inflammation(53.23%),22 as GIN Ⅰ(17.74%), 16 as CIN Ⅱ(12.90% ), 8 as CIN Ⅲ(6.45%) ,4 as cervical squamoas carcinoma (3.23%) and 8 as condyloma (6.45%). The positive rate of HPV in groups of ASCUS were higher than those with negative HPV (P<0.003). Conclusion Women with ASCUS should be tested for HPV. Cervical biopsy under colposcopy is recommended for women with HR-HPV infection.
