The influence of waist circumference on insulin resistance and nonalcoholic fatty liver disease in apparently healthy Korean adults.
10.3350/cmh.2013.19.2.140
- Author:
Deok Yun JU
1
;
Young Gil CHOE
;
Yong Kyun CHO
;
Dong Suk SHIN
;
Su Hyeon YOO
;
Seo Hyoung YIM
;
Ji Yong LEE
;
Jung Ho PARK
;
Hong Joo KIM
;
Dong Il PARK
;
Chong Il SOHN
;
Woo Kyu JEON
;
Byung Ik KIM
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. choyk2004.cho@samsung.com
- Publication Type:Original Article
- Keywords:
Waist circumference;
Insulin resistance;
Nonalcoholic fatty liver disease
- MeSH:
Adult;
Alanine Transaminase/blood;
Area Under Curve;
Asian Continental Ancestry Group;
Body Mass Index;
Cross-Sectional Studies;
Fatty Liver/*diagnosis;
Female;
Humans;
*Insulin Resistance;
Male;
Middle Aged;
Odds Ratio;
Republic of Korea;
Risk Factors;
*Waist Circumference
- From:Clinical and Molecular Hepatology
2013;19(2):140-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Waist circumference (WC) is a risk factor for metabolic syndrome and is related to insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to determine the association between WC and IR and NAFLD in apparently healthy Korean adults. METHODS: The volunteers included in this cross-sectional study comprised 9,159 adults (5,052 men, 4,107 women) who participated in a comprehensive health checkup program. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR) and was considered to be present when the HOMA-IR score was >2. NAFLD was evaluated by ultrasound examination. Elevated alanine aminotransferase (ALT) was defined as >40 IU/L in men and >35 IU/L in women. Logistic regression was performed to determine the odds ratios (ORs) and 95% confidence intervals (95% CIs) for NAFLD, IR, and ALT according to categorized levels of WC. RESULTS: NAFLD was found in 2,553 (27.9%) of the participants (82.6% men, 17.4% women), while IR and elevated ALT were found in 17.2% (68.1% men, 31.9% women) and 10% (83% men, 17% women), respectively. After adjusting for confounding factors, the prevalence of NAFLD, IR, and elevated ALT was significantly associated with increases in WC quartile: highest quartile for NAFLD in men, OR=15.539, 95% CI=12.687-19.033; highest quartile for NAFLD in women, OR=48.732, 95% CI=23.918-99.288 (P<0.001); and highest quartile for IR in men, OR=17.576, 95% CI=13.283-23.255; highest quartile for IR in women, OR=11.078, 95% CI=7.813-15.708 (P<0.001); highest quartile for elevated ALT in men, OR=7.952, 95% CI=6.046-10.459; and highest quartile for elevated ALT in women, OR=8.487, 95% CI=4.679-15.395 (P<0.001). CONCLUSIONS: WC contributes to IR and NAFLD in apparently healthy Korean adults, and thus may be an important factor in the development of IR and NAFLD.
