The studies on early warning of Lens culinaris-reactive α-Fetoprotein (AFP-L3) detecting in primary hepatocellular carcinoma
10.3760/cma.j.issn.1003-9279.2008.05.006
- VernacularTitle:甲胎蛋白异质体L3预警原发性肝癌的研究
- Author:
Yong-Li LI
1
;
Hong-Bin MA
;
Jing-Xia GUO
;
Jia-Bin SHI
;
Jun XU
;
Ai-Xia LIU
;
Li-Hua YANG
;
Bo-An LI
;
Yuan-Li MAO
Author Information
1. 解放军第302医院
- Keywords:
Alpha-fetoproteins;
Carcinoma;
hepatocellular
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(5):336-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of Lens culinaris-reactive α-Fetoprotein (AFP-L3) detection in primary hepatocellular carcinoma. Methods AFP-L3 was isolated by using microspincolumn coupled with lens culinaris agglutinin (LCA), AFP and AFP-L3 were detected with chemiluminescent immunoassay, the propertion of AFP L3 levels were calculated, and the relationship between the elevated AFP-L3 (%) levels and benign and malignant liver disease was analyzed. Results There were significant differences in positive rate between the patients of HCC, suspected HCC and other liver disease (81.80%, 73.68%, 11.80%, respectively, P ＜ 0.05). Among the undetermined HCC (suspected HCC, liver disease) patients, 12 out of 21 cases of AFP-13 positive were diagnosed to be HCC within 6 months, and 6 of them were diagnosed to be the single small HCC at the early stage through B-Ultrasonic Diagnosis or CT. Among 62 cases of AFP-L3 negative, 3 cases were diagnosed to be HCC within 6 months and the risk of occurrence of HCC for AFP-L3 positive increased 11.9 times. Conclusion AFP-L3 has no correlation with AFP value, and it can be used as an independent HCC diagnosis factor. The detection of AFP-L3 has a significant implication for the identification of benign or malignant liver disease and the early stage predictive diagnosis of HCC while AFP increases
