Level of serum and liver tissue TGF-β1 in patients with liver fibrosis due to chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2008.05.012
- VernacularTitle:血清和肝组织TGF-β1与慢性乙型肝炎肝纤维化的关系
- Author:
Jian-Chun GUO
1
;
Jian-Feng BAO
;
Qun-Wei CHEN
;
Xiao-Ou LI
;
Jun-Ping SHI
;
Guo-Qiang LOU
;
Wei-Zhen SHI
;
Yun-Hao XUN
Author Information
1. 浙江中医药大学附属杭州第六医院
- Keywords:
Transforming growth factor beta;
Liver cirrhosis;
Hepatitis B virus;
Hepatitis/diagnosis
- From:
Chinese Journal of Experimental and Clinical Virology
2008;22(5):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the level of Serum and liver tissue TGF-β1 in patients with chronic hepatitis B, to study their relation to liver fibrosis and gain the evidence for diagnosis of liver fibrosis. Methods The liver fibrosis grades(S0-S4) of 131 cases with chronic HBV infection were diagnosed after liver biopsy. Serum TGF-β1 was detected by enzyme-linked immunosorbent assay, and the semiquantitative analysis was applied after detecting the expression of TGF-β1 in liver tissue with immunohistochemistry. Their relations to liver fibrosis were analyzed. Results Serum and tissue level of TGF-β1 increased significantly with the development of fibrosis, and the same result was obtained between themselves(P＜0.01). There was very significant difference for Serum level of TGF-β1 among the groups with different fibrosis grades (P＜0.01). Serum levels of TGF-β1 were decreased significantly comparing the Group S0 or S1 to S4(P＜0.005). There were significant difference for Serum level of TGF-β1 among S0 and the others(P＜0.005). And there was significant difference between S1 and S3(P＜0.005) .The expression level of TGF-β1 in liver tissue has no significant difference between group S3 and S4 (P＞0.05). However, the differences were significantly among the others comparisons(P＜0.01). Conclusion There is close relation between the level of TGF-β1 and the different liver fibrosis grades due to chronic hepatitis B. The serum level of TGF-β1 is a potential noninvasive maker for diagnosis of liver fibrosis.
