Study on prognostic factors of chronic severe hepatitis

VernacularTitle:慢性重型肝炎的预后研究
Author: Qing-Hua MENG ¹ ; Zhong-Hui DUAN ; Juan LI ; Hong-Wei YU ; Jian ZHANG ; Ya ZHANG ; Wei HOU ; Ya LIU
Author Information

1. 首都医科大学附属北京佑安医院
Keywords: Hepatitis; chronic; Prognosis; Logistic models
From: Chinese Journal of Experimental and Clinical Virology 2008;22(5):358-361
CountryChina
Language:Chinese
Abstract: Objective To analyze factors influencing prognosis and to develop a prognosis predicting model for patients with chronic severe hepatitis. Methods Clinical data from 408 patients suffering from chronic severe hepatitis were divided into improved group and deteriorated group. The main clinical and laboratory variables were analyzed as predictive factors of prognosis with logistic regression analysis. Results It was shown that age, sex, Tbil, Dbil, [Cl-], [Na+], WBC, MCV, PT, NH3, PIA, and BUN were different between the two groups with statistical significance (P ＜ 0.05). The prognosis predicting model was P=1/(1+e-y), Y=- 4.636+0.022X1+0.034X2+0.096X3+0.047X4-0.042X5, (X1-age, X2-Tbil, X3-BUN, X4-MCV, X5-PTA) .Conclusion Age, Tbil, BUN, MCV and PTA are the independent risk factors related to prognosis of chronic severe hepatitis.