Comparative study of fibronectin gene expression in tissues from hypertrophic scars and diabetic foot ulcers.
- Author:
Xiaobing FU
1
;
Yinhui YANG
;
Tongzhu SUN
;
Yaping WANG
;
Zhiyong SHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Cicatrix, Hypertrophic; metabolism; Diabetic Foot; metabolism; Female; Fibronectins; biosynthesis; genetics; Gene Expression; Humans; Male; Middle Aged; RNA, Messenger; genetics
- From: Chinese Medical Sciences Journal 2002;17(2):90-94
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the expression characteristic of fibronectin gene in hypertrophic scars and diabetic ulcer tissues.
METHODSThe biopsies from normal skins, hypertrophic scars and diabetic foot ulcers were taken. The technique of quantitative polymerase chain reaction (PCR) was used to evaluate the gene expression of fibronectin in the above biopsies.
RESULTSFibronectin gene expression was enhanced in hypertophic scars and decreased in diabetic foot ulcers compared with that in normal skins. Quantitative comparison showed about 2-fold increase of fibronectin mRNA level in hypertrophic scars and about 3-fold decrease of fibronectin mRNA level in diabetic ulcers as compared with that in normal skins.
CONCLUSIONSFibronectin gene expression is influenced by the tissue environment. Different expression and synthesis of fibronectin may cause different outcomes in wound healing.
