Stem cell maintenance in a different niche.
10.5653/cerm.2013.40.2.47
- Author:
Jeong Mook LIM
1
;
Ji Yeon AHN
;
Seung Tae LEE
Author Information
1. WCU Biomodulation Program, Seoul National University, Seoul, Korea. limjm@snu.ac.kr
- Publication Type:Review
- Keywords:
Non-cellular niche;
Stem cells;
Self-renewal;
Three-dimensional;
Extracellular matrix
- MeSH:
Extracellular Matrix;
Phenotype;
Regenerative Medicine;
Stem Cells
- From:Clinical and Experimental Reproductive Medicine
2013;40(2):47-54
- CountryRepublic of Korea
- Language:English
-
Abstract:
To overcome the difficulty of controlling stem cell fate and function in applications to regenerative medicine, a number of alternative approaches have been made. Recent reports demonstrate that a non-cellular niche modulating the biophysical microenvironment with chemical factors can support stem cell self-renewal. In our previous studies, early establishment was executed to optimize biophysical factors and it was subsequently found that the microgeometry of the extracellular matrix made huge differences in stem cell behavior and phenotype. We review here a three-dimensional, non-cellular niche designed to support stem cell self-renewal. The characteristics of stem cells under the designed system are further discussed.
