Assessment of diastolic function in patients with hypertrophic cardiomyopathy by Doppler tissue imaging.
- Author:
Jing LI
1
;
Yan-ling LIU
;
Hao WANG
;
Xiu-zhang LÜ
;
Hong-chang YANG
;
Fu-jian DUAN
;
Zhen-hui ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cardiomyopathy, Hypertrophic; diagnostic imaging; physiopathology; Diastole; physiology; Echocardiography, Doppler; methods; Humans; Middle Aged; Ventricular Function, Left
- From: Chinese Medical Sciences Journal 2004;19(3):203-206
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine the clinical application of pulsed Doppler tissue imaging in assessing the left ventricular diastolic function and in discriminating between normal subjects and patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction.
METHODSWe measured the peak diastolic velocities of mitral annulus in 81 patients with hypertrophic cardiomyopathy with various stages of diastolic dysfunction and 50 normal volunteers by Doppler tissue imaging using the apical window at 2-chamber and long apical views, respectively. The myocardial velocities were determined with use of variance F statistical analysis.
RESULTSEarly diastolic myocardial velocities of mitral annulus were higher in normal subjects than in patients with hypertrophic cardiomyopathy with either delayed relaxation, pseudonormal filling, or restrictive filling. However, peak myocardial velocities of mitral annulus during atrial contraction were similar in normal subjects and patients with hypertrophic cardiomyopathy.
CONCLUSIONDoppler tissue imaging can directly reflect upon left diastolic ventricular function. Early phase of diastole was the best discriminator between control subjects and patients with hypertrophic cardiomyopathy.